Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55.
应用类型
WB,IHC-F,IHC-P,ICC/IF,ELISA
免疫原
The antiserum was produced against synthesized peptide derived from human TSG101. AA range:281-330
