The tumor suppressor protein p21 Waf1/Cip1 acts as an inhibitor of cell cycle progression. It functions in stoichiometric relationships forming heterotrimeric complexes with cyclins and cyclin-dependent kinases. In association with CDK2 complexes, it serves to inhibit kinase activity and block progression through G1/S. However, p21 may also enhance assembly and activity in complexes of CDK4 or CDK6 and cyclin D.
应用类型
ICC/IF,WB,IHC-F,IHC-P,ELISA
免疫原
The antiserum was produced against synthesized peptide derived from human p21 Cip1. AA range:111-160
