- 中文名称
RPN1 polyclonal antibody
- 英文名字
- RPN1 polyclonal antibody
- 供应商
- Bioworld
- 产品货号
- BS8389
- 产品报价
- ￥询价/50ul
- 产品说明书
- 点击查看
- 购买方式
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- 产品新闻
- 背景资料
- The proteasome is a multisubunit protease responsible for degrading proteins conjugated to ubiquitin. Substrates are targeted for proteolysis by the ubiquitin pathway by the addition of a polyubiquitin chain before being degraded by the 26S proteasome. The 26S proteasome is made up of two subunits, the 20S proteolytic subunit and the 19S regulatory particle, which recognizes and unfolds ubiquitinated proteins. The ubiquitinlike domains (Ubls) of Ubiquitin-like proteins Rad23 and Dsk2 bind both polyubiquitin chains and the 19S regulatory particle (RP) of the 26S proteasome . The Ubl domain mediates the binding of Rad23 to proteasomes, which in turn promotes DNA repair and modulates protein degradation, possibly by delivering ubiquitinylated cargo to proteasomes . Rad23 binds proteasomes by directly interacting with the base subcomplex of the regulatory particle of the proteasome . A component of the base, Rpn1, specifically recognizes the UBL domain of Rad23 through its leucine-rich-repeat-like (LRR-like) domain. Rpn1, for regulatory-particle non-ATPase subunit 1, is one of the largest subunits of proteasome . Base subunit Rpn10, however, does not mediate the binding of UBL proteins to the proteasome in yeast, although it can contribute to the binding of ubiquitin chains by intact proteasomes .
- 应用类型
- WB, IHC
- 免疫原
- Recombinant full length Human RPN1.
- 来源宿主
- Rabbit
- 反应性
- Human, Mouse, Rat
- 保存建议
- Store at 4
- 其他
- Bioworld是专一服务于生命科学研究的专业技术型企业，Bioworld品牌创立以来拥有10000多种常规产品现货，现有8000多种现货抗体，以及其他IVD原料，蛋白等现货产品。在细胞信号通路、免疫学、蛋白组学上拥有显著优势，其抗体产品、生长因子、IVD原料等为生命科学科研工作者提供了极大的便利
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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