Plays a role in viral egress via lysosomal trafficking. Forms homotetrameric ion channels (viroporin localized at endosomes and lysosomes, that may induce deacidification of lysosomes, allowing safe egress of virions via lysosomal trafficking. Also blocks autolysosomes formation by binding and sequestering the host component VPS39 for homotypic fusion and protein sorting (HOPS on late endosomes. This prevents fusion of autophagosomes with lysosomes, disrupting autophagy and facilitating virus egress.
应用类型
WB
免疫原
A synthetic peptide of coronavirus ORF3A(YP_009724391.1).
