Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3' and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
应用类型
WB
免疫原
Recombinant fusion protein of human LRRFIP1(NP_001131024.1).
