PLC-XD2 (PI-PLC X domain-containing protein 2) is a 305 amino acid protein that contains a domain that is present in many PLC isozymes, the PI-PLC X (X-box)domain. Both the X-box domain and the Y-box domain are important for catalytic activity in PLC proteins. X-box domains are conserved from prokaryotes to mammals. The gene encoding PLC-XD2 maps to human chromosome 3, which is made up of about 214 million bases encoding over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. There are two isoforms of PLC-XD2 that are produced as a result of alternative splicing events.
