DSPE-Polysarcosine100 is a lipid-polypeptoid conjugate based on the endogenous amino acid sarcosine (N-methylated glycine) with an average of 100 sarcosine units. The DSPE, 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine, comprises phosphorylethanolamine phospholipid acylated with C18:0 fatty acids. Polysarcosine has been shown to have a higher protein secretion with a reduced immunostimulatory response was observed when compared to systems based on polyethylene glycol (PEG) lipids. DSPE-Polysarcosine can be used in lipid formulas to create lipid nanoparticles (LNPs) for therapeutic application of messenger RNA.
