t-butyl ester-PEG25-Amide-Tri(3-methoxypropanamide-PEG23-Azide) Methane is a branched PEG linker containing three azide groups and a tert-butyl ester. The azide groups can be ligated to alkynes, BCN, DBCO via click chemistry to form stable triazoles, while the t-butyl ester can be deprotected under acidic or basic conditions for use in coupling with primary amines or other nucleophiles. Large PEG linkers improve aqueous and alter pharmacokinetics.
