PLGA(10k)-PEG(5k)-MAL is a maleimide terminated amphiphilic polymer which can react with thiol (SH) at pH 6.5-7.5 via formation of thioether linkage. In water, the polymer self assembles to form micelles with poly(lactide-co-glycolide) (PLGA) core being shielded from the water by PEG shell. The polymer can be used to prepare drug loaded nanoparticles for drug delivery. Reagent grade, for research purpose.