中文名称

重组FGFR-1α（IIIc）-Fc，人

英文名字

RecombinantFGFR-1α(IIIc)-Fc,Human

供应商

Bioworld

产品货号

BK0354

产品报价

￥询价/10ug

产品说明书

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购买方式

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产品新闻

背景资料

Fibroblast Growth Factor Receptor-1 (FGFR-1) is a transmembrane tyrosine kinase receptor belonging to the FGFR family. FGFR family has 4 members, FGFR-1 to FGFR-4, and they all have similar structural characteristics with 3 extracellular immunoglobulin-like (Ig) domains. FGFRs bind to FGFs with the second and third Ig domains, and complex with heparin sulfate when binding. The binding to FGF induces the dimerziation of FGFR and the phosphorylations of the intracellular tyrosines. Furthermore, the phosphorylated FGFR activates downstream signaling pathways, including STAT/JAK, RAS/MAPK, and PI3 K/AKT. Particularly, the signaling of FGFR-1 is stronger than that of FGFR-2, and sustains longer than that of FGFR-4. FGFR-1 is involved in the breast cancer: the patients with the FGFR-1 amplification are more likely to develop distant metastases, and the amplification of FGFR-1 is significantly associated with a shorter overall survival. Recombinant human FGFR-1 alpha(IIIc)-Fc (rhFGFR-1 alpha(IIIc)-Fc) produced in Sf9 is a single glycosylated polypeptide chain containing 592 amino acids. A fully biologically active molecule, rhFGFR-1 alpha(IIIc)-Fc has a molecular mass of around 90 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.

序列

RPSP TLPEQAQPWG APVEVESFLV HPGDLLQLRC RLRDDVQSIN WLRDGVQLAE SNRTRITGEE VEVQDSVPAD SGLYACVTSS PSGSDTTYFS VNVSDALPSS EDDDDDDDSS SEEKETDNTK PNPVAPYWTS PEKMEKKLHA VPAAKTVKFK CPSSGTPNPT LRWLKNGKEF KPDHRIGGYK VRYATWSIIM DSVVPSDKGN YTCIVENEYG SINHTYQLDV VERSPHRPIL QAGLPANKTV ALGSNVEFMC KVYSDPQPHI QWLKHIEVNG SKIGPDNLPY VQILKTAGVN TTDKEMEVLH LRNVSFEDAG EYTCLAGNSI GLSHHSAWLT VLEALEERPA VMTSPLYLEG SGSGSGSPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK

来源宿主

SF9 insect cells

溶解建议

Reconstituted in ddH2O at 100 μg/mL.

保存建议

Lyophilized recombinant human FGFR-1 alpha(IIIc)-Fc (rhFGFR-1 alpha(IIIc)-Fc) remains stable up to 6 months at -80

其他

Bioworld是专一服务于生命科学研究的专业技术型企业，Bioworld品牌创立以来拥有10000多种常规产品现货，现有8000多种现货抗体，以及其他IVD原料，蛋白等现货产品。在细胞信号通路、免疫学、蛋白组学上拥有显著优势，其抗体产品、生长因子、IVD原料等为生命科学科研工作者提供了极大的便利

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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