- 中文名称
成纤维细胞生长因子23(全长) Elisa试剂盒
- 英文名字
- FGF23 (intact) ELISA Kit
- 供应商
- Biomedica Immunoassays
- 产品货号
- BI-20700
- 产品报价
- ￥12x8tests
- 产品说明书
- 点击查看
- 购买方式
- 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- FGF23 (fibroblast growth factor 23) is a member of the fibroblast growth factor family and controls phosphate and vitamin D homeostasis. The full-length protein comprises 251 amino acids including a 24 amino acid signal peptide. The N-terminal FGF homology region of FGF23 is separated from the unique C-terminal region by a proteolytic cleavage site. A proportion of FG23 is proteolytically processed between arginine179 and serine180 to generate N-terminal and C-terminal fragments. Therefore, the major forms of FGF23 present in human circulation are hormonally intact FGF23 and inactive N-terminal and C-terminal fragments. FGF23 binds to FGF receptor 1c (FGFR1c) with its N-terminal region, while the C-terminal region is capable of interacting with the co-receptor αKlotho to confer high-affinity binding to the receptor. FGFR1c and αKlotho are expressed in the distal nephron and the parathyroid gland. Co-receptor independent signaling of FGF23 has been described for other FGFRs, which are expressed in a variety of tissues. The main source of FGF23 are osteocytes in the bone.
- 产品描述
- Method
Sandwich ELISA, HRP/TMB, 12×8-well detachable strips
Sample type
Plasma (EDTA, citrate, heparın), serum, urine, cell culture supernatant
Sample volume
50 µl / well
Assay time
3 h / 30 min
Sensitivity
5.4 pg/ml (= 0.21 pmol/l)
Standard range
0 – 1 600 pg/ml (= 0 – 60.8 pmol/l)
Conversion factor
1 pg/ml = 0.038 pmol/l; MW: 26 kDa
Specificity
Endogenous and recombinant human intact FGF23.
Cross-reactivity
The assay does not cross-react with FGF3, FGF19, and FGF21.
Precision
In-between-run (n=9): ≤ 6 % CV
Within-run (n=3): ≤ 8 % CV
- 产品特点
- 保存建议
- +4°C
- 其他
- Biomedica Immunoassay(bmgrp)公司成立于1988年, 总部位于奥地利维也纳，主要致力于研究、开发和生产基于ELISA方法用于临床前研究相关标记物检测的工具。迄今为止Biomedica Immunoassay公司在心血管检测及骨代谢检测领域开发了一系列特色ELISA检测试剂盒，Biomedica Immunoassay的生产过程符合GMP/GLP指南，并符合ISO 9001:2015管理体系，有CE认证。Biomedica Immunoassay的产品根据FDA， EMEA和ICH指南进行验证，并具有验证报告。
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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