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ELISA试剂盒
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中文名称

成纤维细胞生长因子23(全长) Elisa试剂盒

英文名字
FGF23 (intact) ELISA Kit
供应商
Biomedica Immunoassays
产品货号
BI-20700
产品报价
¥12x8tests
产品说明书
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产品新闻
背景资料
FGF23 (fibroblast growth factor 23) is a member of the fibroblast growth factor family and controls phosphate and vitamin D homeostasis. The full-length protein comprises 251 amino acids including a 24 amino acid signal peptide. The N-terminal FGF homology region of FGF23 is separated from the unique C-terminal region by a proteolytic cleavage site. A proportion of FG23 is proteolytically processed between arginine179 and serine180 to generate N-terminal and C-terminal fragments. Therefore, the major forms of FGF23 present in human circulation are hormonally intact FGF23 and inactive N-terminal and C-terminal fragments. FGF23 binds to FGF receptor 1c (FGFR1c) with its N-terminal region, while the C-terminal region is capable of interacting with the co-receptor αKlotho to confer high-affinity binding to the receptor. FGFR1c and αKlotho are expressed in the distal nephron and the parathyroid gland. Co-receptor independent signaling of FGF23 has been described for other FGFRs, which are expressed in a variety of tissues. The main source of FGF23 are osteocytes in the bone.
产品描述
Method Sandwich ELISA, HRP/TMB, 12×8-well detachable strips Sample type Plasma (EDTA, citrate, heparın), serum, urine, cell culture supernatant Sample volume 50 µl / well Assay time 3 h / 30 min Sensitivity 5.4 pg/ml (= 0.21 pmol/l) Standard range 0 – 1 600 pg/ml (= 0 – 60.8 pmol/l) Conversion factor 1 pg/ml = 0.038 pmol/l; MW: 26 kDa Specificity Endogenous and recombinant human intact FGF23. Cross-reactivity The assay does not cross-react with FGF3, FGF19, and FGF21. Precision In-between-run (n=9): ≤ 6 % CV Within-run (n=3): ≤ 8 % CV
产品特点
保存建议
+4°C
其他
Biomedica Immunoassay(bmgrp)公司成立于1988年, 总部位于奥地利维也纳,主要致力于研究、开发和生产基于ELISA方法用于临床前研究相关标记物检测的工具。迄今为止Biomedica Immunoassay公司在心血管检测及骨代谢检测领域开发了一系列特色ELISA检测试剂盒,Biomedica Immunoassay的生产过程符合GMP/GLP指南,并符合ISO 9001:2015管理体系,有CE认证。Biomedica Immunoassay的产品根据FDA, EMEA和ICH指南进行验证,并具有验证报告。
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