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细胞分析试剂盒
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中文名称
NGFR / p75ECD快速ELISA试剂盒:人(1个板)
英文名字
NGFR/p75ECD Rapid ELISA Kit: Human (1 Plate)
供应商
Biosensis
产品货号
BEK-2219-1P
产品报价
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Biosensis
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背景资料
The nerve growth factor (NGF) receptor (NGFR), also known as p75 neurotrophin receptor (p75NTR; TNFRS16; CD271) is a common receptor for the neurotrophins NGF, BDNF, NT-3 and NT-4/5. In neurons, p75NTR mediates a variety of physiological functions including survival, apoptosis, neurite outgrowth and synaptic plasticity. A potential pathological role for p75NTR has become evident in recent years. Altered p75NTR expression levels are implicated in degeneration of spinal motor neurons in human and mouse models of amyotrophic lateral sclerosis (ALS). Importantly, the extracellular domain of p75NTR (p75ECD) is shed from the cell membrane and excreted in urine. Recent findings further suggest that p75ECD could be an early biomarker for ALS in humans, as significantly elevated p75ECD levels are found in urine of ALS patients as compared to healthy controls.
产品描述
This ELISA kit consists of a pre-coated mouse monoclonal anti-p75 ECD capture antibody, a biotinylated mouse monoclonal anti-p75 ECD detection antibody and horseradish peroxidase (HRP)-conjugated streptavidin. The addition of a substrate (3,3,5,5-tetramethylbenzidine, TMB) yields a colored reaction product which is directly proportional to the concentration of p75 ECD present in samples and protein standards. A human p75 ECD positive control (QC sample) is provided to assure consistent assay performance.
This NGFR/p75 ECD ELISA kit employs an in-house recombinant human p75 ECD-Fc chimera as standard that has been validated against an externally available p75 ECD-Fc protein. While there is a current lack of a commercially available, true human p75 ECD standard, this ELISA kit allows quantification of human p75 ECD as p75 ECD-Fc human equivalents. Please note that the antibodies used in this ELISA do not cross-react with mouse p75 ECD.
Note: For research use only. Not for diagnostic and clinical purposes.
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