中文名称

烂烴-C8-pApG

英文名字

Alkyne-C8-pApG

供应商

Baseclick

产品货号

BCT-41-S

产品报价

￥询价/1umol

产品说明书

点击查看

购买方式

银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868

产品新闻

背景资料

烂烴-C8-pApG(Alkyne-C8-pApG)背景资料,请查看该产品的使用说明书

产品描述

In molecular biology, the 5′-cap structure of mRNA plays a central role in the stability of mRNA and in the initiation of translation traditional methods for synthesizing cap analogs are often labor-intensive, producing low yields and time-consuming. However, recent advances have introduced a new approach using click chemistry, specifically copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), to produce phosphate-modified cap analogs.This innovative method enables the efficient synthesis of 5′-cap mimics by combining two nucleotide units, resulting in a linear dinucleotide cap analog, with a free clickable moiety. Like our alkyne-C8-5′- phosphoadenylyl- (3′ −> 5′)- guanosine (pApG or 5′-p(rA)p(rG)). This enables you to produce easy different cap structures by clicking to conventional cap structures with corresponding azide modified nucleotide.In addition, click labeling of mRNA at 5’-end with e.g. targeting agents, protective entities to prevent degradation, or fluorescent dyes. These cap analog not only increase mRNA stability but also improve translation efficiency, making them highly valuable for research and therapeutic applications, including RNA-based vaccines and gene replacement therapies.Several cap analogs have been identified, when incorporated into mRNA, exhibit comparable translational efficiency after clicking to conventional cap structures. This breakthrough opens new possibilities for the development of chemically modified mRNAs that can be used in various biomedical applications, offering a promising future for mRNA-based treatments.

产品形式

Liquid

保存建议

-20 °C, 避光, 干燥, 无RNA酶

其他

Baseclick于2008成立于2008年德国慕尼黑，BaseClick的核心竞争力源于其专有的铜催化叠氮-炔环加成（CuAAC）点击化学技术。该技术由2001年诺贝尔化学奖得主Barry Sharpless教授发明，BaseClick拥有在核酸领域应用该技术的全球独家许可。相比传统方法，点击化学具有反应迅速、条件温和、产率高、选择性强等显著优势，可实现从小分子寡核苷酸到大基因片段的高效、精准功能化修饰。目前的应用领域包括：核酸标记技术、Edu细胞增殖试验，PCR标记试剂盒，FISH探针，（高度）修饰的寡核苷酸等等，Baseclick跟Thermo Fisher，Roche，Merck，abcam，BD Bioscience等诸多知名品牌建立了合作关系。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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