L-α-羟基戊二酸二钠盐产品是L-α-Hydroxyglutaric Acid is metabolized to 2-oxoglutarate or α-ketoglutarate by L-2-hydroxyglutarate dehydrogenase. Rare defects in L-2-hydroxyglutarate dehydrogenase cause a neurometabolic disorder characterized by 2-hydroxyglutaric aciduria. High concentrations of L-α-Hydroxyglutaric Acid inhibit histone lysine demethylases, which might promote oncogenesis. 2-hydroxyglutarate can be used in the collection buffer to improve HIF-1α recovery from tumor specimens.