PF-03814735产品是PF-03814735 is an ATP-competitive inhibitor of Aurora kinases A and B with IC₅₀values of 0.8 and 0.5 nM respectively. It has shown to block cytokinesis, inhibit cellular proliferation in many tumor cell lines including HCT-116, HL-60 and A549. In vitro experiments have shown that PF 03814735 inhibits the phosphorylation of Aurora B H3 and Aurora A cultured MDA-MB-231 cells.