Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy. In analogy to many other amyloid associated disorders, alpha-synuclein may also form oligomeric assemblies. These small and soluble forms have been suggested to exert a stronger tissue damaging effect as compared to the monomeric and fibrillar counterpart. Using a recently developed technique a monoclonal oligomer-specific antibody has been designed.
应用类型
ELISA (ELISA)
免疫原
Synthetic peptide derived from human alpha-synuclein Glu131-Ala140
来源宿主
小鼠
反应性
人
保存建议
For short time storage add sodium azide and store at +4
