Autophagy-related protein 7 functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1. Formation of the final GABARAPL1-PE conjugate is essential for autophagy.
A synthetic peptide corresponding to the C-terminal of human APG7 protein conjugated to blue carrier protein has been used as the immunogen, The peptide is homologous with the corresponding sequence derived from APG7 protein in mouse, rat, S, cerevisiae, Macaca mulatta (monkey) and Canis familiaris (dog),
