Bifunctional PEG2-based crosslinker which has terminal alkyne and alkyl iodide groups. Alkyl iodides are among the most powerful alkylators. They alkylate various O-, S-, N- and C-nuclophiles. This reactive derivative can be used for the preparation of different molecules with terminal alkyne groups. Terminal alkyne is a versatile synthon that participates in Sonogashira coupling and Click chemistry reactions.