TLR7 belongs to the Toll-like receptor （TLR） family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns （PAMPs） which are expressed on infectious agents， and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR7 is principally expressed in lung， placenta， and spleen， and lies in close proximity to TLR8， on chromosome X.
应用类型
ELISA， Western blot
免疫原
Anti-human TLR7 mAb， is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TLR7 amino acids 451-500 purified from E. coli.
