α-Conotoxin PIA is a peptide toxin originally isolated from Conus purpurascens and belongs to the A superfamily of Conotoxins. It is a selective antagonist for heteromeric α6 subunit -containing nicotinic Acetylcholine Receptors (nAChR). α-Conotoxin PIA binds on the extracellular portion of the nAChR and distinguishes α6 from α3 subunits due to its lower affinity for α3