μ-conotoxin BuIIIC, is a peptide toxin originally isolated from Conus Bullatus (Bubble cone). It has the characteristic arrangement of six-cysteine residues (-CC-C-C-CC-) and comprises 26 amino acid residues. μ-conotoxin BuIIIC was demonstrated to be a potent irreversible inhibitor of the voltage-gated Na+ channel skeletal muscle subtype NaV1.4, expressed in Xenopus oocytes. 1 μM toxin was shown to block 96% of the channel. The novel structural determinants of BuIIIC along with its ability to potently inhibit NaV1.4 make this conotoxin useful in defining features of the NaV1.4 pharmacophore and thereby facilitate the design of highly subtype-specific ligands that target NaV1.4.
产品描述
A Blocker of NaV1.4 Channel
产品形式
μ-conotoxin BuIIIC, is a peptide toxin originally isolated from Conus Bullatus (Bubble cone). It has the characteristic arrangement of six-cysteine residues (-CC-C-C-CC-) and comprises 26 amino acid residues. μ-conotoxin BuIIIC was demonstrated to be a potent irreversible inhibitor of the voltage-gated Na+ channel skeletal muscle subtype NaV1.4, expressed in Xenopus oocytes. 1 μM toxin was shown to block 96% of the channel. The novel structural determinants of BuIIIC along with its ability to potently inhibit NaV1.4 make this conotoxin useful in defining features of the NaV1.4 pharmacophore and thereby facilitate the design of highly subtype-specific ligands that target NaV1.4.
