ω-Conotoxin CVIC is a peptide toxin originally isolated from the cat cone (Conus Catus). It is a blocker of voltage gated N-,P- and Q type CaV channels. CVIC has an effective concentration of 10-50 nM with an IC50 of 7.6 nM for N-type channels and 31nM for P- and Q-type channels. Compared to other ω-Conotoxins CVIC is a fairly poor inhibitor of N-type channels and only a moderate inhibitor of P- and Q-type channels. Cloning and sequencing of mRNA transcripts from the venom ducts of the sea-snail failed to isolate CVIC’s mRNA transcript thus suggesting that this ω-Conotoxin is not found abundantly in the Conus Catus species, and may be found in other species of the cone snail family
