ω-Conotoxin CVIB is a peptide toxin originally isolated from the cat cone (Conus Catus). It is a blocker of voltage gated N-,P- and Q type CaV channels. CVIB has an effective concentration of 1-10nM with an IC50 of 7.7 nM for N-type channels and 11nM for P- and Q-type channels. Compared to other ω-Conotoxins, CVIB is a fairly poor inhibitor of N-type channels and only a moderate inhibitor of P- and Q-type channels. Cloning and sequencing of mRNA transcripts from the venom ducts of the sea-snail failed to isolate CVIB’s mRNA transcript thus suggesting that this ω-Conotoxin is not found abundantly in the Conus Catus species and may be found in other species of the cone snail family
