Paxilline is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include Penitrem A (#P-650) and Verruculogen (#V-500). Paxilline enhanced the electrically induced twitch contractions in guinea pig ileum, without influencing the contractions provoked by exogenous acetylcholine.Paxilline was shown to inhibit the peptidyle toxin resistant combination a+b4 channels (for more background see ) expressed in CHO cells. It was shown to be as potent as Iberiotoxin (#STI-400) in action potential broadening in hippocampus and amygdala.
产品描述
A Mycotoxin Blocker of KCa1.1 (BK) Channels
产品形式
Paxilline is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include Penitrem A (#P-650) and Verruculogen (#V-500). Paxilline enhanced the electrically induced twitch contractions in guinea pig ileum, without influencing the contractions provoked by exogenous acetylcholine.Paxilline was shown to inhibit the peptidyle toxin resistant combination a+b4 channels (for more background see ) expressed in CHO cells. It was shown to be as potent as Iberiotoxin (#STI-400) in action potential broadening in hippocampus and amygdala.
