PiMA was found to be a potent opener of KCa1.1 (large conductance Ca2+ activated K+ (BK)) channels. 1 µM PiMA doubled the current carried via BK channels and this effect increased dose dependently. PiMA increases the open probability of single BK channels by shifting both its voltage and Ca2+ dependence to more hyperpolarized voltages. BK channels that were activated by PiMA retain their charybdotoxin sensitivity.
产品描述
A Novel Opener of KCa1.1 Channels
产品形式
PiMA was found to be a potent opener of KCa1.1 (large conductance Ca2+ activated K+ (BK)) channels. 1 µM PiMA doubled the current carried via BK channels and this effect increased dose dependently. PiMA increases the open probability of single BK channels by shifting both its voltage and Ca2+ dependence to more hyperpolarized voltages. BK channels that were activated by PiMA retain their charybdotoxin sensitivity.
保存建议
艾美捷为您提供的Alonmone Labs原装进口的Pimaric Acid (PiMA) (5 x 1 mg)产品可室温运输,建议您在收到产品后将其置于合适的温度下保存。