Parthenolide is a sesquiterpene lactone found in Mexican-Indian medicinal plants such as Tanacetum parthenium. It has been widely used in indigenous medical practices for the treatment of migraine, inflammation and tumors. Parthenolide inhibits IkB kinase (IKK) and IKKβ (the upstream activators of the Nuclear Factor-kB (NF-kB) pathway), thus inhibiting Interleukin 1- and tumor necrosis factor a (TNFα) without affecting the activation of p38 and c-Jun N-terminal kinase.
产品描述
A Nuclear Factor-κB (NF-κB) Pathway Inhibitor
产品形式
Parthenolide is a sesquiterpene lactone found in Mexican-Indian medicinal plants such as Tanacetum parthenium. It has been widely used in indigenous medical practices for the treatment of migraine, inflammation and tumors. Parthenolide inhibits IkB kinase (IKK) and IKKβ (the upstream activators of the Nuclear Factor-kB (NF-kB) pathway), thus inhibiting Interleukin 1- and tumor necrosis factor a (TNFα) without affecting the activation of p38 and c-Jun N-terminal kinase.
