Pilsicainide is a class IC anti-arrhythmic drug widely used in the treatment of supraventricular and ventricular tachyarrhythmias in Japan. Results from voltage clamp experiments show that Pilsicainide is a pure Na+ channel blocker with little or no effect on other cardiac channels, probably with the exception of HERG channels.
产品描述
A Use Dependent Anti-Arrhythmic Nav Channel Blocker
产品形式
Voltage-gated Na+ channels (VGSC, Nav) are critically important for electrogenesis and nerve impulse conduction. Certain Na+ channel isoforms are predominantly expressed in peripheral sensory neurons associated with pain sensation, and the expression and functional properties of Nav in peripheral sensory neurons can be dynamically regulated following axonal injury or peripheral inflammation.
