Meclofenamic acid (meclofenamate) acts as a KCNQ2/Q3 channel opener by causing a hyperpolarizing shift of the voltage activation curve and by slowing down the deactivation kinetics leading to membrane hyperpolarization1. Its EC50 value is reported to be 25 μM1. KCNQ2 (Kv7.2) and KCNQ3 (Kv7.3) are voltage-gated K+ channel subunits that underlie the neuronal M current (IM), a noninactivating, slowly deactivating subthreshold K+ current that opposes depolarizing current and act to stabilize membrane potential and control neuronal excitability
