Lys-Bradykinin is an endogenous nonspecific agonist for BKRB1and BKRB2, with some specificity towards the BKRB2. Activation of Bradykinin receptors with Lys-Bradykinin may induce intracellular Ca2+ elevation. 100 nM Lys-Bradykinin induced Ca2+ transients in rat aortic endothelium cells (RAEC) (see figure here and review in reference #8).
产品描述
A Ligand of B2 Bradykinin G-Protein Coupled Receptor
产品形式
Kinins are small peptides rapidly produced following tissue injury that serve as important modulators of inflammation and pain. In the periphery, the actions of kinins include vasodilatation, increased vascular permeability, stimulation of immune cells, and induction of pain. Kinins in the central nervous system (CNS) appear to initiate a similar cascade of events leading to neural tissue damage as well as long lasting disturbances affecting blood-brain barrier function.
