The majority of Na+ channels in the mammalian heart are Tetrodotoxin (TTX) insensitive Nav1.5. nThe putative structure of NaV1.5 consists of four homologous domain (I-IV), each containing six transmembrane segments (S1-S6). Mutations in the C-terminus of NaV1.5 were described in connection to Long QT syndrome and Brugada syndrome.Recent data have demonstrated selective expression of NaV1.5 in the mouse central nervous system and implicated a role for NaV1.5 in the physiology of the central nervous system
应用类型
经验证，该抗体可应用于IC、IFC、IH、WB等实验应用，也可用于 IP等实验。
免疫原
Human NaV1.5抗体的免疫原肽段为含特定氨基酸残基的GST融合蛋白：1978-2016位氨基酸残基，该序列来源于人类Nav1。5 (Accession编号为# Q14524), (MW: 33 kDa。)。胞内, C端。
