Protease-activated receptor 4 (PAR-4) belongs to a family of four G protein-coupled receptors (PAR-1 - 4) that are activated as a result of proteolytic cleavage by certain serine proteases, hence their name. In this novel modality of activation, a specific protease cleaves the PAR receptor within a defined sequence in its extracellular N-terminal domain. This results in the creation of a new N-terminal tethered ligand, which subsequently binds to a site in the second extracellular loop of the same receptor. This binding results in the coupling of the receptor to G proteins and in the activation of several signal transduction pathways
应用类型
经验证，该抗体可应用于IC、IFC、IH、LCI、WB等实验应用，也可用于 IP等实验。
免疫原
Protease-activated 受体-4 (胞外)抗体的免疫原肽段为(C)HLRGQRWPFGEAA(S)R。此免疫原序列来源于136-150位氨基酸残基，该序列来源于人类PAR-4 (Accession编号为 Q96RI0 )。 Cys 149 was replaced with Ser，第二胞外环。
