Protease-activated receptor 1 (PAR-1) belongs to a family of four G protein-coupled receptors (PAR-1 - 4) that are activated as a result of proteolytic cleavage by certain serine proteases, hence their name. In this novel modality of activation, a specific protease cleaves the PAR receptor within a defined sequence in its extracellular N-terminal domain. This results in the creation of a new N-terminal tethered ligand, which subsequently binds to a site in the second extracellular loop of the same receptor. This binding results in the coupling of the receptor to G proteins and in the activation of several signal transduction pathways.
应用类型
经验证，该抗体可应用于IC、IFC、IH、LCI、WB, 也可用于 IP等实验。
免疫原
Human Protease-activated 受体-1 (胞外)抗体的免疫原肽段为(C)KNESGLTEYRLVSINK。此免疫原序列来源于61-76位氨基酸残基，该序列来源于人类PAR-1 (Accession编号为P25116)。 胞外, N端。
