The P2X receptors belong to the ligand-gated ion channel family and are activated by extracellular ATP. P2X receptors are involved in synaptic communication and in diseases of the nervous system. The P2X receptors family consist of at least seven isoforms: P2X1-P2X7.nAll P2X subunits can assemble to form homomeric or heteromeric functional channels with the exception of P2X6, which only seems to function as part of a heteromeric complex.The P2X6 receptor assembles to a heteromultimer with two other P2X subunits, P2X2 and P2X4. nThe P2X6 receptor is extensively expressed throughout the central nervous system
