MATE2 carrier is part of the SLC47 family encoded by the SLC47A2 gene, predominantly expressed in apical brush border membranes of the proximal tubules in kidneys. It exhibits proton gradient dependent secretion of cationic drugs across the membrane. It is predicted to have 12 transmembrane helices similar to other MATE family members but also an additional COOH-terminal helix. Histidine and Cysteine residues in positions 382, 59 and 123 respectably are required for MATE2 proper functioning
