The Nectin family is known as cell-cell adhesion molecules and comprises four members in this family: nectin-1, nectin-2, nectin-3 and nectin-4 which are encoded by PVRL1, PVRL2, PVRL3, and PVRL4 genes respectively1. They are Ca2+-independent immunoglobulin-like CAMs and are able to trans-interact1.They are localized at adherens junctions between two neighboring cells and binds to afadin through their C-terminal region.Nectin-2 acts as mediator of herpes simplex virus invasion into host cell. A single nucleotide polymorphism in PVRL2 shows an association with later onset of Alzheimers Disease
