Potassium chloride cotransporters (KCCs) are members of cation chloride cotransporter gene superfamily (Slc12 family). This family consists of sodium potassium two chloride cotransporter 1 (NKCC1) and 2 (NKCC2), sodium chloride cotransporte (NCC) and KCCs1. All of these transporters mediate electroneutral transport of cations coupled with one or two Cl- and contribute to regulation of cell volume and homeostasis of intracellular Cl- concentration. KCCs extrude one K+ with one Cl- from intracellular space to the extracellular space by using the chemical gradient of K+ as the driving force of Cl- extrusion
