- 中文名称
有机阳离子转运蛋白1抗体（50 ul）
- 英文名字
- Anti-Organic Cation Transporter 1
- 供应商
- Alomone
- 产品货号
- ALO-ACT-011-50
- 产品报价
- ￥已停产
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868。
- 产品新闻
- 背景资料
- Organic cation transporters belong to the Solute carrier family 22 (SLC22) and the MATE family. The SLC22 family contains the three subtypes of passive diffusion organic cation transporters called OCT1 (SLC22A1), OCT2 (SLC22A2) and OCT3 (SLC22A3). OCT1 is responsible for the uptake of organic cationic compounds from blood to hepatocytes.nLike most members of the SLC22 family, the organic cation and carnitine transporters have a predicted membrane topology that comprises 12 α-helical transmembrane domains (TMDs), an intracellular N-terminus, a large glycosylated extracellular loop, a large intracellular loop with phosphorylation sites and an intracellular C-terminus.nIn humans, OCT1 has a broad tissue distribution, although it is primarily expressed in hepatocytes. In rat hepatocytes, Oct1 has been located at the sinusoidal membrane4. OCT1 is also expressed in cholangiocytes5. Human OCT1 is also expressed at the apical membrane of epithelial cells in the proximal and distal tubules of the nephron.nA recent study demonstrated that primary liver cancer derived from epithelial cells, namely, hepatocellular carcinoma (HCC), cholangiocarcinoma (CGC), and hepatoblastoma, shares a decreased expression of OCT1 as a common feature7. The reduction in the expression levels of this transporter has been associated with advanced tumor stages and poorer overall patient survival rates in HCC and CGC5.
- 应用类型
- 经验证，该抗体可应用于WB等实验应用，也可用于IC、IFC、IH、IP等实验。
- 免疫原
- Organic Cation Transporter 1抗体的免疫原肽段为(C)ENLGRRKSKAKENT。此免疫原序列来源于530- 543 位氨基酸残基，该序列来源于大鼠Organic Cation Transporter 1 (Accession编号为Q63089)。胞内, C端
- 来源宿主
- 兔
- 反应性
- 反应性：小鼠、 大鼠
- 保存建议
- 艾美捷为您提供的Organic Cation Transporter 1抗体(50 ul)为室温运输，建议您收到产品后﹣20℃保存。
- 其他
- Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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