The mammalian melastatin-related transient receptor potential (TRPM) is a subfamily of the TRP family. The family was named after the first discovered member melastatin (TRPM1) whose gene was identified in metastatic and benign melanomas. The TRPM family consist of eight members designated as TRPM1-8 that can be further divided into four pairs: TRPM1 and TRPM3; TRPM2 and TRPM8; TRPM4 and TRPM5; and TRPM6 and TRPM7.The TRPM proteins share structural homology with other members of the TRP superfamily channels; six putative transmembrane domains, and cytoplasmic N-terminus and C-terminus. However, due to their long N-terminus and C-terminus they were also named the long TRP channel family. TRPM channels were suggested to play a role in tumourigenesis, proliferation and differentiation.Recently, TRPM1 was found to be down-regulated in a highly metastatic line. The loss of TRPM1 expression has been reported to be correlated to melanoma aggressiveness.nTwo alternative splice variants of TRPM1 were reported; short (TRPM1-S) and long (TRPM1-L). The TRPM1-S was described to be expressed at human melanocyte and mainly in metastasic melanoma cell lines. While TRPM1-L is expressed at murine CNS.
应用类型
经验证，该抗体可应用于WB等实验应用，也可用于 IC、IFC、IH、IP等实验。
免疫原
Human TRPM1抗体的免疫原肽段为(C)EEKKVKKEKASTETE。此免疫原序列来源于1518-1533位氨基酸残基，该序列来源于人类TRPM1 (Accession编号为O75560)。胞内, C端。
