All α1-Adrenoceptors (α1-ARs) activate phospholipases C and A.In addition to mobilizing intracellular calcium, the α1-ARs have also been shown to activate calcium influx via voltage-dependent and independent calcium channels.n The α1B-Adrenoceptor shows the highest levels in the spleen, kidney, cerebellum, and fetal brain.α1B Adrenoceptor causes contraction of smooth muscle cells and thereby controls vascular tone, blood pressure, and accelerates the development of atherosclerosis.
