- 中文名称
GLP-2 ELISA
- 英文名字
- GLP-2 ELISA
- 供应商
- Ansh Labs
- 产品货号
- AL-174
- 产品报价
- ￥询价/96wellmicrotiter
- 产品说明书
- 点击查看
- 购买方式
- 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Glucagon-Like Peptide-2 (GLP-2) is a 33-amino acid gut hormone produced by the intestinal L-cells and various neurons in the central nervous system1-3. Posttranslational proteolytic cleavage of proglucagon molecule produces GLP-2 along with GLP-1. Intestinal GLP-2 is co-secreted along with GLP-1 upon nutrient ingestion. GLP-2 is released in response to stimulation by luminal nutrients, such as glucose, fatty acids and dietary fiber4. GLP-2 is cleaved by proteolytic enzymes into active form (1-33) and inactive form (3-33). The GLP-2 sequence is highly conserved among mammals and is involved in regulating gut mucosal growth and integrity. The main biological actions of GLP-2 are related to the regulation of energy absorption and maintenance of mucosal morphology, function and integrity of the intestine; however, recent experimental animal studies suggested that GLP-2 exerts beneficial effects on glucose metabolism in conditions related to increased uptake of energy, such as obesity. GLP-2 acts in an endocrine fashion to link intestinal growth and metabolism with nutrient intake4. GLP-2 acts as a beneficial factor for glucose metabolism in mice with high-fat diet-induced obesity5. GLP-2 and related analogs may be used as therapeutics for short bowel syndrome, Crohn's disease, osteoporosis and as adjuvant therapy during cancer chemotherapy. Measuring plasma levels of GLP-2 in research, preclinical and clinical studies of Type 2 Diabetes and obesity will open new avenue for diagnostics and therapeutics.
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nReferences:
n1. Müller et al., (2017) The New Biology and Pharmacology of Glucagon. Physiol Rev 97: 721–766.
n2. Drucker DJ, Habener JF, Holst JJ Discovery, characterization, and clinical development of the glucagon-like peptides (2017) J Clin Invest. 127(12):4217-4227.
n3. Vrang N, Hansen M, Larsen PJ & Tang-Christensen M 2007 Characterization of brainstem preproglucagon projections to the paraventricular and dorsomedial hypothalamic nuclei. Brain Research 1149 118–126
n4. Amato A, Baldassano and Flavia Mulè. GLP2: an underestimated signal for improving glycaemic control and insulin sensitivity. Journal of Endocrinology (2016) 229, R57–R66
n5. Baldassano S, Amato A, Rappa F, Cappello F & Mulè F (2016b) Influence of endogenous glucagon like peptide-2 on lipid disorders in mice fed a high fat diet. Endocrine Research.
nVol. 41, Iss. 4,
n6. HHS Publication, 5th ed., 2007. Biosafety in Microbiological and Biomedical Laboratories. Available http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5
n7. DHHS (NIOSH) Publication No. 78–127, August 1976. Current Intelligence Bulletin 13 - Explosive Azide Hazard. Available: http:// www.cdc.gov/niosh.
n8. Kricka L. Interferences in immunoassays – still a threat. Clin Chem 2000; 46: 1037–1038.
- 产品描述
- The Glucagon-like peptide-2 (GLP-2) enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of GLP-2 in EDTA plasma and other biological fluids.
- 产品特点
- 保存建议
- Store at 2 to 8°C until expiration date.
- 其他
- Ansh labs是开发和生产免疫检测试剂盒和定制生物技术检测产领创者，总部位于美国休斯敦，公司产品遍及全球80多个国家。公司于2011年成立，核心团队来自于Diagnostic system laboratory，专注于女性健康和激素检测领域近40年，拥有全球领先的核心技术， 以及多年经验生物技术研发经验的科学家团队，产品覆盖生殖健康，高危妊娠，肿瘤，糖尿病等多个疾病领域，围绕最新的免疫分析技术，多种蛋白和单克隆抗体，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等几十余种试剂产品，也同时涵盖小鼠，大鼠，狗，羊，牛等灵长类多个物种的独特的物种特异性的试剂。
Ansh labs 坐落于美国德克萨斯州，是目前世界上唯一能提供TGF-β超家族所有成员的检测公司，也是最早专注激素类产品研究和新型免疫检测技术的先驱者。优势产品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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