- 中文名称
PAPP-A / Stanniocalcin 2 复合物 ELISA
- 英文名字
- PAPP-A / Stanniocalcin 2 Complex ELISA
- 供应商
- Ansh Labs
- 产品货号
- AL-166
- 产品报价
- ￥询价/96wellmicrotiter
- 产品说明书
- 点击查看
- 购买方式
- 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Mammalian stanniocalcin-2 (STC2) is a secreted polypeptide widely expressed in developing and adult tissues. However, although transgenic expression in mice is known to cause severe dwarfism, and targeted deletion of STC2 causes increased postnatal growth, its precise biological role has remained unknown. STC2 potently inhibits the proteolytic activity of the growth promoting metalloproteinase, pregnancy associated plasma protein-A (PAPP-A). Proteolytic inhibition requires covalent binding of STC2 to PAPPA, and is mediated by a disulfide bond, which involves Cys120 of STC2. Binding of STC2 prevents PAPP-A cleavage of insulin-like growth factor binding protein (IGFBP)-4 and hence release within tissues of bioactive IGF, required for normal growth. Concordantly, STC2 efficiently inhibits PAPP-Amediated IGF receptor signaling in vitro, and that transgenic mice expressing a mutated variant of STC2, STC2(C120A), which is unable to inhibit PAPPA, grow like wild-type mice. STC2 is a novel proteinase inhibitor and a previously unrecognized extracellular component of the IGF system.1
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nREFERENCES
n1. Malene R. Jepsen, Søren Kløverpris , Jakob H. Mikkelsen , Josefine H. Pedersen, Ernst-Martin Füchtbauer, Lisbeth S. Laursen, and Claus Oxvig JBC Papers in Press. Published on December 22, 2014 as Manuscript M114.611665.
- 产品描述
- The PAPP-A Stanniocalcin-2 Complex enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of PAPP-A Stanniocalcin-2 Complex in human serum and other biological fluids.
- 产品特点
- 保存建议
- Store at 2 to 8°C until expiration date.
- 其他
- Ansh labs是开发和生产免疫检测试剂盒和定制生物技术检测产领创者，总部位于美国休斯敦，公司产品遍及全球80多个国家。公司于2011年成立，核心团队来自于Diagnostic system laboratory，专注于女性健康和激素检测领域近40年，拥有全球领先的核心技术， 以及多年经验生物技术研发经验的科学家团队，产品覆盖生殖健康，高危妊娠，肿瘤，糖尿病等多个疾病领域，围绕最新的免疫分析技术，多种蛋白和单克隆抗体，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等几十余种试剂产品，也同时涵盖小鼠，大鼠，狗，羊，牛等灵长类多个物种的独特的物种特异性的试剂。
Ansh labs 坐落于美国德克萨斯州，是目前世界上唯一能提供TGF-β超家族所有成员的检测公司，也是最早专注激素类产品研究和新型免疫检测技术的先驱者。优势产品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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