Stanniocalcin 2 ELISA-Stanniocalcin 2 ELISA代理/参数/厂家-ELISA试剂盒-艾美捷科技有限公司

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中文名称: Stanniocalcin 2 ELISA

英文名字: Stanniocalcin 2 ELISA

供应商: Ansh Labs

产品货号: AL-143

产品报价: ￥询价/96wellmicrotiter

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背景资料: Stanniocalcins, STC1 and STC2 are glycoprotein hormones. They were originally identified in fish, where they regulate calcium and phosphate homeostasis. Human STC2 is a 33.3 kDa protein, known to form disulfide-linked homodimers. The amino acid sequence of STC2 is only 30% identical to STC1, but the glycosylation sites and cysteine residues are conserved. STC2 is phosphorylated by Casein kinase 2. STC2 is widely expressed with most abundant protein expression in brain, adrenal gland, kidney, prostate and small intestine. 1
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nSTC2 function in hormone signaling is indicated by reports showing inhibition of ovarian progesterone biosynthesis and transactivation of androgen receptor.2,3 STC2 exhibits anti-apoptotic functions in cells subjected to endoplasmic reticulum and hypoxic stress by a mechanism involving inhibition of plasma membrane store-operated calcium entry.4,5 STC2 overexpression mice exhibit growth restriction, while knockout mice are larger than wild-type littermates.1 STC2 function in growth regulation was demonstrated by its ability to interact with PAPP-A, potentially inhibiting its proteolytic activity towards IGFBP-4 and causing reduced IGF signaling. 6,7,8 STC2-mediated PAPP-A inhibition was also reported to reduce atherosclerosis in hypercholesterolemic mice. 9
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nIn breast cancer STC2 is induced by estrogen and STC2 expression levels correlate with levels of estrogen receptor. STC2 function in different cancers may involve regulation of cell proliferation, neoplastic transformation and endothelial invasion. STC2 also plays a role in epithelial-mesenchymal transition by activation of MAPK/ERK signaling in hypoxic ovarian cancer cells. STC2 is upregulated in several cancers including, gastric cancer, lung cancer, renal cell carcinoma, colorectal cancer, castration-resistant prostate cancer and cervical cancer.1 Serum STC2 levels may serve as a valuable research tool for diagnosis and prognosis of several cancers and growth defects.
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nReferences:
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n1. Yeung BH, Law AY, Wong CK. 2012. Evolution and roles of stanniocalcin. Mol Cell Endocrinol. 26;349(2):272-80.
n2. Shin J, Sohn YC. 2014. Identification of Ran-binding protein M as a stanniocalcin 2 interacting protein and implications for androgen receptor activity. BMB Rep. 47(11):643-8.
n3. Luo, C.W., Pisarska, M.D., Hsueh, A.J., 2005. Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. Endocrinology 146, 469–476.
n4. Ito, D., Walker, J.R., Thompson, C.S., Moroz, I., Lin, W., Veselits, M.L., Hakim, A.M.,Fienberg, A.A., Thinakaran, G., 2004. Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties. Mol. Cell Biol. 24, 9456–9469.
n5. Zeiger, W., Ito, D., Swetlik, C., Oh-hora, M., Villereal, M.L., Thinakaran, G., 2011. Stanniocalcin 2 is a negative modulator of store-operated calcium entry. Mol.Cell Biol. 31, 3710–3722.
n6. Jepsen MR, Kløverpris S, Bøtkjær JA, Wissing ML, Andersen CY, Oxvig C. 2016.The proteolytic activity of pregnancy-associated plasma protein-A is potentially regulated by stanniocalcin-1 and -2 during human ovarian follicle development. Hum Reprod. 31(4):866-74
n7. Monget P, Oxvig C. 2016. PAPP-A and the IGF system. Ann Endocrinol (Paris). 77(2):90-6
n8. Jepsen MR, Kløverpris S, Mikkelsen JH, Pedersen JH, Füchtbauer EM, Laursen LS, Oxvig C. 2015. Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis. J Biol Chem 6;290(6):3430-9
n9. Steffensen LB, Conover CA, Bjørklund MM, Ledet T, Bentzon JF, Oxvig C.2016. Stanniocalcin-2 overexpression reduces atherosclerosis in hypercholesterolemic mice. Atherosclerosis, 248:36-43
n10. HHS Publication, 5th ed., 2007. Biosafety in Microbiological and Biomedical Laboratories. Available http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5
n11. DHHS (NIOSH) Publication No. 78–127, August 1976. Current Intelligence Bulletin 13 - Explosive Azide Hazard. Available http:// www.cdc.gov/niosh.
n12. Approved Guideline – Procedures for the Handling and Processing of Blood Specimens, H18-A3. 2004. Clinical and Laboratory Standards Institute.
n13. Kricka L. Interferences in immunoassays – still a threat. Clin Chem 2000; 46: 1037–1038.

产品描述: The Stanniocalcin-2 (STC2) enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of Stanniocalcin-2 in human serum and other biological fluids.

产品特点

保存建议: Store at 2 to 8°C until expiration date.

其他: Ansh labs是开发和生产免疫检测试剂盒和定制生物技术检测产领创者，总部位于美国休斯敦，公司产品遍及全球80多个国家。公司于2011年成立，核心团队来自于Diagnostic system laboratory，专注于女性健康和激素检测领域近40年，拥有全球领先的核心技术，以及多年经验生物技术研发经验的科学家团队，产品覆盖生殖健康，高危妊娠，肿瘤，糖尿病等多个疾病领域，围绕最新的免疫分析技术，多种蛋白和单克隆抗体，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等几十余种试剂产品，也同时涵盖小鼠，大鼠，狗，羊，牛等灵长类多个物种的独特的物种特异性的试剂。 Ansh labs 坐落于美国德克萨斯州，是目前世界上唯一能提供TGF-β超家族所有成员的检测公司，也是最早专注激素类产品研究和新型免疫检测技术的先驱者。优势产品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。