- 中文名称
催产调节蛋白 ELISA
- 英文名字
- Oxyntomodulin ELISA
- 供应商
- Ansh Labs
- 产品货号
- AL-139
- 产品报价
- ￥询价/96wellmicrotiter
- 产品说明书
- 点击查看
- 购买方式
- 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Oxyntomodulin was initially identified as a moiety that exhibited glucagon like immunoreactivity and was appropriately named for its ability to modulate the gastric acid secretion in the gastric oxyntic glands.1,2 Oxyntomodulin is a 37 amino acid peptide hormone secreted by the gut endocrine L-cells post-prandially3. Oxyntomodulin and Glucagon, a peptide hormone secreted by the alpha cells of the pancreas, share the identical amino acid sequence in the N-terminal 29 aa with oxyntomodulin having an additional octapeptide in the C-terminus. Upon nutrient ingestion, prohormone convertase1/3 cleaves proglucagon precursor into Oxyntomodulin, GLP-1/2 and GRPP.3
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nOxyntomodulin is known to bind both the GLP-1 receptor (GLP1R) and the glucagon receptor (GCGR), but with lower affinity compared to GLP-1 and glucagon.3
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nOxyntomodulin causes weight loss in obese patients via suppression of food intake and increase in energy expenditure.3 It is reported to have varied tissue-specific effects; and stimulates endocrine pancreas to secrete insulin, somatostatin and glucagon. Oxyntomodulin administration was also reported to increase heart-rate in mice.3 Besides regulating glucose homeostasis in monogastric animals, oxyntomodulin also increases the concentration of insulin and glucose in plasma of Holstein cattle under normal physiological conditions.4 Using mass-spectrometry based profiling of human plasma, it was shown that Type 2 diabetes patients have lower levels of Oxyntomodulin and levels increase more than 10-fold after gastric bypass surgery.5 Oxyntomodulin is therapeutically used to lower glucose levels and suppress appetite resulting in weight loss.
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nReferences:
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n - Unger, R.H., Eisentraut,A.M.,McCall,M.S.,Keller,S.,Lanz,H.C.,Madison,L.L., 1959. Glucagon antibodies and their use for immunoassay for glucagon. Proceedings of the Society for Experimental Biology and Medicine 102:621–623.
n - Bataille, D., Tatemoto,K.,Coudray,A.M.,Rosselin,G.,Mutt,V.,1981.Bioactive ‘enteroglucagon’ (oxyntomodulin):evidence for a C-terminal extension of the glucagon molecule. Comptes Rendus des Séances de l'Académie des Sciences. Série III 293:323–328.
n - Pocai A. 2012. Unraveling oxyntomodulin, GLP1's enigmatic brother. J Endocrinol. 215(3):335-46
n - ThanThan S, Zhao H, Yannaing S, Ishikawa T, Kuwayama H.2010. Oxyntomodulin increases the concentrations of insulin and glucose in plasma but does not affect ghrelin secretion in Holstein cattle under normal physiological conditions. Domest Anim Endocrinol. 39(3):163-70
n - Wewer Albrechtsen NJ et al; 2016. Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma. EBioMedicine.7:112-20.
n - HHS Publication, 5th ed., 2007. Biosafety in Microbiological and Biomedical Laboratories. Available http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5
n - DHHS (NIOSH) Publication No. 78–127, August 1976. Current Intelligence Bulletin 13 - Explosive Azide Hazard. Available: http:// www.cdc.gov/niosh.
n - Kricka L. Interferences in immunoassays – still a threat. Clin Chem 2000; 46: 1037–1038.
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- 产品描述
- The Oxyntomodulin (OXM) ELISA (enzyme linked immunosorbent assay) kit provides materials for the quantitative measurement of oxyntomodulin in K2-EDTA and Li-Heparin plasma and other biological fluids.
- 产品特点
- 保存建议
- Store at 2 to 8°C until expiration date.
- 其他
- Ansh labs是开发和生产免疫检测试剂盒和定制生物技术检测产领创者，总部位于美国休斯敦，公司产品遍及全球80多个国家。公司于2011年成立，核心团队来自于Diagnostic system laboratory，专注于女性健康和激素检测领域近40年，拥有全球领先的核心技术， 以及多年经验生物技术研发经验的科学家团队，产品覆盖生殖健康，高危妊娠，肿瘤，糖尿病等多个疾病领域，围绕最新的免疫分析技术，多种蛋白和单克隆抗体，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等几十余种试剂产品，也同时涵盖小鼠，大鼠，狗，羊，牛等灵长类多个物种的独特的物种特异性的试剂。
Ansh labs 坐落于美国德克萨斯州，是目前世界上唯一能提供TGF-β超家族所有成员的检测公司，也是最早专注激素类产品研究和新型免疫检测技术的先驱者。优势产品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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