雌三醇，未结合 EIA-Estriol, Unconjugated EIA代理/参数/厂家-ELISA试剂盒-艾美捷科技有限公司

PRODUCT CENTER

ELISA试剂盒

产品中心

当前位置：首页 > 产品中心 > 免疫学产品 > ELISA试剂盒

中文名称: 雌三醇，未结合 EIA

英文名字: Estriol, Unconjugated EIA

供应商: Ansh Labs

产品货号: AL-138

产品报价: ￥询价/96wellmicrotiter

产品说明书: 点击查看

购买方式: 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868

产品新闻

背景资料: Estriol (1,3,5(10)-estratriene-3,16α,17β-triol; E3) is one of the 3 major naturally occurring estrogens, the others being estradiol and estrone. Estriol is produced almost exclusively during pregnancy, and is the major estrogen produced in the normal human fetus. During pregnancy, the production of estriol depends on an intact maternal-placental-fetal unit.1,2 Steroid precursors from the maternal circulation are taken up by the placenta and converted to progesterone. Progesterone is then converted to dehydroepiandrosterone sulfate (DHEA-S) in the fetal adrenal gland, which is then 16α-hydroxylated in the fetal liver. 16α-hydroxylase activity is present in only very low amounts in placenta and non-fetal tissues. In the placenta, 16α-hydroxy-DHEA-S is then converted sequentially to 16α-hydroxy-DHEA, 16α-hydroxyandrost-4-ene-3,17-dione and, finally, estriol. Estriol may also originate from estrogen precursors, such as 16α-hydroxyestrone. This pathway may account for the high levels of estrone sulfate found in breast cyst fluid.3
n
nFetal-placental production of estriol leads to a progressive rise in maternal circulating estriol levels, reaching a late-gestational peak which is ~2-3 orders of magnitude greater than non-pregnant levels.1,2 In the maternal circulation, estriol undergoes rapid conjugation in the liver followed by urinary excretion with a half-life of ~20 minutes.1 Therefore, maternal estriol levels can provide a dynamic estimate of fetal production rates. In terms of estrogenic activity, estriol is much less potent than estradiol.2 The physiologic role of estriol is not known.
n
nSpecific diagnostic and therapeutic uses for estriol measurements are not completely defined, although clinical utility during pregnancy has been investigated. Since normal estriol production depends on an intact maternal-placental-fetal circulation and functional fetal metabolism, maternal estriol levels have been used to monitor fetal status during pregnancy, particularly during the third trimester. Because estriol concentrations are subject to diurnal and episodic variation, it is common practice to refer serum measurements to a baseline, defined for the patient as either the average or the highest of her three most recent estriol results. However, studies in diabetic pregnancies suggest that low estriol levels have limited value in predicting fetal distress.4 The AL-138 Unconjugated Estriol EIA uses a rabbit anti-estriol antibody preparation with low cross-reactivity to other natural estrogens and estrogen precursors.
n
nReferences:
n
n1. Buster JE: Gestational changes in steroid hormone biosynthesis, secretion, metabolism, and action. Clin Perinatol 10:527-552, 1983.
n2. Cañez MS, Lee KJ, Olive DL: Progestogens and estrogens. Infertil Reproduct Med Clin North Amer 3:59-78, 1992.
n3. Levitz M, Raju U, Arcuri F, Brind JL, Vogelman JH, Orentreich N, Granata OM, Castagnetta L: Relationship between the concentrations of estriol sulfate and estrone sulfate in human breast cyst fluid. J Clin Endocrinol Metab 75:726-729, 1992.
n4. Miodovnik M, Mimouni F, Hertzberg VS, Siddiqi TA, Tsang RC: Serum unconjugated estriols in insulin-dependent diabetic pregnancies: normative data and clinical relevance. Am J Perinatol 5:327-333, 1988.
n5. HHS Publication, 5th ed., 2007. Biosafety in Microbiological and Biomedical Laboratories. Available http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5
n6. Approved Guideline – Procedures for the Handling and Processing of Blood Specimens, H18-A3. 2004. Clinical and Laboratory Standards Institute.
n7. Kricka L. Interferences in immunoassays – still a threat. Clin Chem 46: 1037–1038, 2000.

产品描述: The Unconjugated Estriol Enzyme Immunoassay (EIA) Kit provides materials for the quantitative measurement of unconjugated estriol in serum.

产品特点

保存建议: Store at 2 to 8°C until expiration date.

其他: Ansh labs是开发和生产免疫检测试剂盒和定制生物技术检测产领创者，总部位于美国休斯敦，公司产品遍及全球80多个国家。公司于2011年成立，核心团队来自于Diagnostic system laboratory，专注于女性健康和激素检测领域近40年，拥有全球领先的核心技术，以及多年经验生物技术研发经验的科学家团队，产品覆盖生殖健康，高危妊娠，肿瘤，糖尿病等多个疾病领域，围绕最新的免疫分析技术，多种蛋白和单克隆抗体，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等几十余种试剂产品，也同时涵盖小鼠，大鼠，狗，羊，牛等灵长类多个物种的独特的物种特异性的试剂。 Ansh labs 坐落于美国德克萨斯州，是目前世界上唯一能提供TGF-β超家族所有成员的检测公司，也是最早专注激素类产品研究和新型免疫检测技术的先驱者。优势产品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。