- 中文名称
卵泡抑素 ELISA
- 英文名字
- Follistatin ELISA
- 供应商
- Ansh Labs
- 产品货号
- AL-117
- 产品报价
- ￥询价/96wellmicrotiter
- 产品说明书
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- 购买方式
- 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Follistatin (FST) is a glycosylated single-chain protein that is expressed in a wide variety of tissues.1 Activin stimulates pituitary FSH secretion whereas Inhibin and Follistatin are inhibitory.2 Follistatin has been shown to be a potent activin-binding protein which acts by neutralizing the actions of the Activins.3 The activin-follistatin binding complex is generally considered to be composed of one activin and two follistatin molecules, and the affinity of binding between follistatin and activin is similar to that of activin for its receptor. Several isoforms of follistatin of molecular weight 31 – 39 kDa have been identified. Molecular analysis of the isoforms indicate that follistatin is encoded by a single gene and that the variety of isoforms arise from alternative splicing, glycosylation and proteolytic cleavage. Alternative splicing occurs at the 3’-terminal of the gene resulting in a precursor form of 317 and 344 amino acids4, and then following subsequent cleavage of the 29 amino acid signal peptide, generates 2 mature follistatin isoforms of 288 and 315 amino acids (namely Follistatin-288 and Follistatin-315).
nThe ratio of Follistatin isoforms present in different tissues and bodily fluids varies, as does their relative binding affinities. Follistatin-288 is the predominant form present in human follicular fluid; whereas the main form in serum is Follistatin-315.5 Follistatin-288 has a greater capacity to bind and neutralize activin and is approximately 10-fold more potent than Follistatin-315 in suppressing FSH secretion from rat pituitary cells in vitro. In addition, Follistatin-288 also binds with much greater affinity to heparin sulfate proteoglycans located on the cell surface and extracellular matrix, indicating that the Follistatin-288 isoform is primarily a membrane-bound form of Follistatin, whereas Follistatin-315 is a circulating form.
n
nReferences:
n1. Lin SY et al. Reproduction. 126(2):133-148, 2003.
n2. Robertson DM et al. Biochem Biophys Res Commun. 126(1):220-226, 1985.
n3. Nakamura T et al. Science. 247(4944):836-838, 1990.
n4. Shimasaki S et al. Biochem Biophys Res Commun. 152(2):717-723, 1988.
n5. Schneyer AL et al. Endocrinology. 137(1):240-247, 1996.
n6. HHS Publication, 5th ed., 2007. Biosafety in Microbiological and Biomedical Laboratories. Available http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5
n7. DHHS (NIOSH) Publication No. 78–127, August 1976. Current Intelligence Bulletin 13 - Explosive Azide Hazard. Available http:// www.cdc.gov/niosh.
- 产品描述
- The Follistatin enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of follistatin in human serum and other biological fluids.
- 产品特点
- 保存建议
- Store at 2 to 8°C until expiration date.
- 其他
- Ansh labs是开发和生产免疫检测试剂盒和定制生物技术检测产领创者，总部位于美国休斯敦，公司产品遍及全球80多个国家。公司于2011年成立，核心团队来自于Diagnostic system laboratory，专注于女性健康和激素检测领域近40年，拥有全球领先的核心技术， 以及多年经验生物技术研发经验的科学家团队，产品覆盖生殖健康，高危妊娠，肿瘤，糖尿病等多个疾病领域，围绕最新的免疫分析技术，多种蛋白和单克隆抗体，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等几十余种试剂产品，也同时涵盖小鼠，大鼠，狗，羊，牛等灵长类多个物种的独特的物种特异性的试剂。
Ansh labs 坐落于美国德克萨斯州，是目前世界上唯一能提供TGF-β超家族所有成员的检测公司，也是最早专注激素类产品研究和新型免疫检测技术的先驱者。优势产品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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