法新社 ELISA-AFP ELISA代理/参数/厂家-ELISA试剂盒-艾美捷科技有限公司

PRODUCT CENTER

ELISA试剂盒

产品中心

当前位置：首页 > 产品中心 > 免疫学产品 > ELISA试剂盒

中文名称: 法新社 ELISA

英文名字: AFP ELISA

供应商: Ansh Labs

产品货号: AL-104

产品报价: ￥询价/96wellmicrotiter

产品说明书: 点击查看

购买方式: 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868

产品新闻

背景资料: Alpha-Fetoprotein (AFP) is a 68 kDa protein which is produced primarily during fetal life by the fetal liver yolk sac.1 Elevated AFP levels are seen in patients with nonseminomatous testicular cancer. More than 95% of testicular cancers belong to a heterogeneous group called germ-cell tumors because it is widely believed that they arise in primordial germ cells.2 Germ cell tumors (GCTs) are classified either as seminomatous or as nonseminomatous. The latter can be further classified as embryonal carcinoma, teratoma, or choriocarcinoma. The seminoma histologic subtype can be found in 40% of all germ cell tumors while the nonseminoma histologic subtype can be found in 60% of germ cell tumors.3 The different histologic types of germ cell tumors may occur singly or in various combinations. Elevated AFP levels have been observed in patients diagnosed as having seminomatous testicular cancer with nonseminomatous elements, but not in patients with pure seminoma.4-9
n
nBoth AFP and hCG are measured in testicular cancer. Approximately 40% of patients with nonseminomatous germ cell tumors have elevation of only one marker.10 During the clinical course of the disease, the levels of the two markers do not always parallel each other.
n
nA direct relationship has been observed between the incidence of elevated AFP levels in nonseminomatous testicular cancer, and the stage of the disease.4-6 Elevation of AFP (>10 IU/L or 12.1 ng/mL) occurs in 80% of metastatic and in 57% of stage 1 nonseminomatous germ cell tumors.10 In Clinical Stage 2B or higher, AFP and/or hCG are elevated in 65-80% of the cases with increasing frequency according to the bulk of the disease.12
n
nThe usefulness of AFP measurements in the management of nonseminomatous testicular cancer patients undergoing cancer therapy has been well established.4,6,13 Current management of testicular germ cell tumors relies upon the use of serum tumor markers, which can indicate the presence of small foci of active tumor that cannot be detected by currently available imaging techniques.10 Markers augment and complement information obtained from radiographic and other staging procedures.14 Also, the short half-lives of tumor markers facilitate their use in assessing tumor burden during therapy. AFP has a serum half-life of 3.5 - 6 days.15 AFP and/or hCG levels are elevated before orchiectomy in about 60% of all Clinical Stage I patients but follow a normal decline after the testicle is removed.12
n
nFor patients in clinical remission following treatment, AFP levels generally decrease6. Post-operative AFP levels which fail to return to normal strongly suggest the presence of residual tumor.4,6,16 Following successful resection of primary or metastatic disease, AFP and hCG decline at a rate proportional to their respective half-lives.15 An elevated actual half-life of serum markers following orchiectomy or retroperitoneal lymph node dissection may indicate the presence of occult, persistent disease.14
n
nAs recently as the 1970s, nonseminomatous germ cell tumors were often fatal. Due to advances in chemotherapy, most patients are cured, even those with disseminated disease.2 The clinical use of AFP and hCG measurements has been essential to this success. Many patients have a marker surge during the first week of chemotherapy, presumably secondary to tumor lysis. AFP may increase from 20% to 200% over pretreatment levels.14 Chemotherapeutic responses are accompanied by a decline in marker levels. Persistent marker elevation is usually the result of residual malignancy. Rising marker values may occur before or after clinical recurrence and one marker may rise in discordance with the other.14 Tumor recurrence is often accompanied by a rise in serum AFP values prior to clinical evidence of progressive disease.4-5
n
nElevated serum levels of AFP are also associated with some non-testicular cancers. Increased serum concentrations of AFP were first observed in human subjects with primary heptocellular carcinoma.11 Subsequently, elevated serum AFP values have been associated with other malignant diseases such as teratocarcinoma (with yolk sac components) of the ovary, endodermal sinus tumors, certain gastrointestinal tumors (with and without liver metastasis), and tumors of other tissues.12-13, 16-20 A study performed at the National Institutes of Health and the Mayo Clinic demonstrated elevated AFP values in patients with pancreatic, gastric, colon, and lung cancer.14
n
nIn additional studies, AFP was elevated in 60-80% of patients with hepatocellular cancer, in 23% of patients with gastrointestinal cancer and in 10% of patients with liver metastasis from various tumor types.12 However, a normalization of markers does not mean that all viable tumor has been eliminated.14
n
nNotably however, elevated serum AFP concentrations have also been reported in patients with noncancerous diseases such as ataxia telangiectasia, heredity tyrosinemia, neonatal hyperbilirubinemia, acute viral hepatitis, chronic active hepatitis, cirrhosis, and other benign hepatic conditions. 14,16,21-26 AFP is modestly elevated (up to 100 ng/mL) in 20% of patients with non-malignant liver disease.12 Due to its lack of specificity for malignant conditions, AFP testing is not recommended as a screening procedure to detect cancer in the general population.

产品描述: The AFP Enzyme-Linked Immunosorbent Assay (ELISA) Kit provides materials for the quantitative measurement of AFP in serum.

产品特点

保存建议: Store at 2 to 8°C until expiration date.

其他: Ansh labs是开发和生产免疫检测试剂盒和定制生物技术检测产领创者，总部位于美国休斯敦，公司产品遍及全球80多个国家。公司于2011年成立，核心团队来自于Diagnostic system laboratory，专注于女性健康和激素检测领域近40年，拥有全球领先的核心技术，以及多年经验生物技术研发经验的科学家团队，产品覆盖生殖健康，高危妊娠，肿瘤，糖尿病等多个疾病领域，围绕最新的免疫分析技术，多种蛋白和单克隆抗体，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等几十余种试剂产品，也同时涵盖小鼠，大鼠，狗，羊，牛等灵长类多个物种的独特的物种特异性的试剂。 Ansh labs 坐落于美国德克萨斯州，是目前世界上唯一能提供TGF-β超家族所有成员的检测公司，也是最早专注激素类产品研究和新型免疫检测技术的先驱者。优势产品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。