- 中文名称
牛 GDF-15 ELISA
- 英文名字
- Bovine GDF-15 ELISA
- 供应商
- Ansh Labs
- 产品货号
- AL-1021
- 产品报价
- ￥询价/96wellmicrotiter
- 产品说明书
- 点击查看
- 购买方式
- 90%产品中国有现货库存。银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Growth/differentiation Factor 15 (GDF-15, also called as MIC-1, NAG-1 and NRG-1, Uniprot: Q99988) is a divergent member of the TGF-b superfamily of growth factors. It is encoded in humans by a gene in chromosome 19. The human GDF-15 gene encodes for a protein of 308 amino acid residues which consists of a signal sequence (residues 1-29), pro-domain (30-194) and mature growth factor domain (195-308). The protein is secreted from the producing cell and the precursor containing the pro- and mature domains is proteolytically processed by furin-like protease, typically in the Golgi complex, but sometimes also an unprocessed protein is secreted. Two mature domains dimerize forming a typical TGF-b-like structure with four b-strands and an a-helix in each protomer, with an interfacial disulfide stabilizing the mature growth factor. The molecular weight of a mature GDF-15 dimer is 25 kDa.
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nGDF-15 expression in healthy subjects is abundant in placenta, followed by the prostate and very low levels in the bladder, kidney, colon, stomach, liver, gall bladder, pancreas, and endometrium(1-3). GDF-15 is expressed by cardiomyocytes, adipocytes, macrophages, endothelial and vascular smooth muscle cells(4). High circulating GDF-15 concentration are in general related to inflammation, myocardial ischemia, and cancer except for in pregnancies. It is often induced under stress to maintain cell and tissue homeostasis(5-6).
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nThe circulating GDF-15 levels in cows and its biological role has not been explored.
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nReferences:
n1. Kamiya R, Asakura S. Helical transformations of Salmonella flagella in vitro. J Mol Biol. (1976) 106:167–86. doi: 10.1016/0022-2836(76)90306-5
n2. Nazarova NY, Chikhirzhina GI, Tuohimaa P. Calcitriol induces transcription of the placental transforming growth factor β gene in prostate cancer cells via an androgen-independent mechanism. Mol Biol. (2006) 40:72–6. doi: 10.1134/S0026893306010110.
n3. Uhlen M, Fagerberg L, Hallstrom BM, Lindskog C, Oksvold P, Mardinoglu A, et al. Tissue-based map of the human proteome. Science. (2015) 347:1260419. doi: 10.1126/science.1260419.
n4. Tsai VWW, Husaini Y, Sainsbury A, Brown DA, Breit SN. The MIC-1/GDF15-GFRAL pathway in energy homeostasis: implications for obesity, cachexia, and other associated diseases. Cell Metab. (2018) 28:353–68. doi: 10.1016/j.cmet.2018.07.018
n5. Adela R, Banerjee SK. GDF-15 as a target and biomarker for diabetes and cardiovascular diseases: a translational prospective. J Diabetes Res. (2015) 2015:490842. doi: 10.1155/2015/490842
n6. Guenancia C, Kahli A, Laurent G, Hachet O, Malapert G, Grosjean S, et al. Pre-operative growth differentiation factor 15 as a novel biomarker of acute kidney injury after cardiac bypass surgery. Int J Cardiol. (2015) 197:66–71. doi: 10.1016/j.ijcard.2015.06.012.
- 产品描述
- The Bovine GDF-15 enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of GDF-15 in bovine serum.
- 产品特点
- 保存建议
- Store at 2 to 8°C until expiration date.
- 其他
- Ansh labs是开发和生产免疫检测试剂盒和定制生物技术检测产领创者，总部位于美国休斯敦，公司产品遍及全球80多个国家。公司于2011年成立，核心团队来自于Diagnostic system laboratory，专注于女性健康和激素检测领域近40年，拥有全球领先的核心技术， 以及多年经验生物技术研发经验的科学家团队，产品覆盖生殖健康，高危妊娠，肿瘤，糖尿病等多个疾病领域，围绕最新的免疫分析技术，多种蛋白和单克隆抗体，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等几十余种试剂产品，也同时涵盖小鼠，大鼠，狗，羊，牛等灵长类多个物种的独特的物种特异性的试剂。
Ansh labs 坐落于美国德克萨斯州，是目前世界上唯一能提供TGF-β超家族所有成员的检测公司，也是最早专注激素类产品研究和新型免疫检测技术的先驱者。优势产品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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