PECheck PAPP-A2 ELISA-PECheck PAPP-A2 ELISA代理/参数/厂家-ELISA试剂盒-艾美捷科技有限公司

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中文名称: PECheck PAPP-A2 ELISA

英文名字: PECheck PAPP-A2 ELISA

供应商: Ansh Labs

产品货号: AL-1015

产品报价: ￥询价/96wellmicrotiter

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背景资料: Pregnancy associated plasma protein-A2 (PAPP-A2) is a metalloproteinase protein identified as a homolog of PAPP-A in the metzincin superfamily of pappalysins1-8. PAPP-A2 is a noncovalently linked dimer of two 220-kDa subunits4. PAPP-A2 cleaves insulin-like growth factor-binding protein 5 (IGFBP5) and Insulin like growth factor binding protein 34. PAPP-A2 is function as a local regulator of insulin-like growth factor (IGF) bioavailability1-8. PAPP-A2 is expressed in a wide range of tissues and abundantly present in the placental syncytiotrophoblast and the pregnant uterus3. The insulin-like growth factors are important in human embryo implantation and placentation1-8. Numerous studies have identified the associations between the placental levels of PAPP-A2 and preeclampsia1-8. It is being suggested that either altered levels PAPP-A2 cause abnormal placental development, or the production of these proteins is altered to compensate for abnormal placentation1-8. Preeclampsia affects 5% - 7% of all pregnant women and poses threat to maternal and fetal well-being. PAPP-A2 is abundantly expressed in the placenta and have been reported to be significantly elevated in the maternal circulation as well as placentas of pregnancies complicated by preeclampsia. PAPP-A2 showed the highest value to predict preeclampsia-related pregnancy complications when added on top of traditional criteria and shows comparable value to that of the angiogenic markers sFlt-1 (soluble Fms-like tyrosinekinase-1), placental growth factor (PlGF), and sFlt-1/PlGF ratio9.
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nReferences:
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n1. Kløverpris S et al. A robust immunoassay for pregnancy-associated plasma protein-A2 based on analysis of circulating antigen: establishment of normal ranges in pregnancy. Mol Hum Reprod. 2013; 19:756
n2. Crosley EJ et al. First-trimester levels of pregnancy-associated plasma protein A2 (PAPP-A2) in the maternal circulation are elevated in pregnancies that subsequently develop preeclampsia. Reprod Sci. 2014 Jun;21(6):754-60
n3. Kramer et al. Differential expression of human placental PAPP-A2 over gestation and in preeclampsia Placenta 2016; 37: 19-25.
n4. Overgaard MT et al. Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase. J Biol Chem 2001; 276:21849-21853.
n5. Winn VD et al. Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. Endocrinology. 2009; 150 :452-62
n6. Overgaard MT et al. Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the preform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissue. Biol Reprod 1999; 61:1083-1089.
n7. Wagner PK et al. Regulation of pregnancy-associated plasma protein A2 (PAPPA2) in a human placental trophoblast cell line (BeWo). Reprod Biol Endocrinol. 2011 15: 9-48
n8. Hansen YB et al. First trimester PAPP-A2, PAPP-A and hCGβ in small-for-gestational-age pregnancies. Clin Chem Lab Med. 2016; 54:117-23
n9. Neuman R et al. PAPP-A2 and Inhibin A as novel Predictors for Pregnancy Complications in Women with Suspected or Confirmed Preeclampsia. J Ame Heart Assoc 2020; Vol 9-19.

产品描述: The PECheck PAPP-A2 Enzyme-Linked Immunosorbent Assay (ELISA) kit provides materials for the quantitative measurement of PAPP-A2 in human maternal serum and other biological fluids.

产品特点

保存建议: Store at 2 to 8°C until expiration date.

其他: Ansh labs是开发和生产免疫检测试剂盒和定制生物技术检测产领创者，总部位于美国休斯敦，公司产品遍及全球80多个国家。公司于2011年成立，核心团队来自于Diagnostic system laboratory，专注于女性健康和激素检测领域近40年，拥有全球领先的核心技术，以及多年经验生物技术研发经验的科学家团队，产品覆盖生殖健康，高危妊娠，肿瘤，糖尿病等多个疾病领域，围绕最新的免疫分析技术，多种蛋白和单克隆抗体，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等几十余种试剂产品，也同时涵盖小鼠，大鼠，狗，羊，牛等灵长类多个物种的独特的物种特异性的试剂。 Ansh labs 坐落于美国德克萨斯州，是目前世界上唯一能提供TGF-β超家族所有成员的检测公司，也是最早专注激素类产品研究和新型免疫检测技术的先驱者。优势产品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。