USP35 (Ubiquitin Specific Peptidase 35) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. USP35 encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of USP35 is upregulated by the let-7a microRNA and reduced expression has been observed in human tumor tissues.
