UBE2E2 (Ubiquitin Conjugating Enzyme E2 E2) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Ubiquitin mediated proteolysis. GO annotations related to this gene include ligase activity and acid-amino acid ligase activity. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-, as well as Lys-63-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.